Shana Stoddard sitting in front of stained glass windows

Photo by Noah Stewart ’22

RESEARCH INTERESTS

My lab is the “Molecular Immunotherapeutics Research” (MIR) lab.  Our long-term goal is to improve therapy for autoimmune disorders (AD).  Autoimmunity is the #2 cause of long-term chronic illness, with over 23.5 million Americans affected.  Currently 80-100 autoimmune disorders have been identified by scientists.  Idiopathic membranous glomerulonephritis (IMG) is an organ specific AD affecting the kidney glomeruli.  It is the most common cause of nephrotic syndrome with over 30-60% of patients progressing to end stage renal disease (ESRD). 

My research is focused on improving patient outcomes with autoimmune disorders, in particular idiopathic membranous nephritis (IMN), through development of auto-antibody-specific inhibitors, antigen-specific therapies, as well as novel methods for development of antigen specific therapies.  In the MIR lab we accomplish these goals using a combination of computational chemistry, biochemistry, and cell-based assays.

Research site: Stoddard Molecular Immunotherapeutics Research Lab | Computational and Experimental Bio-Organic Chemistry

PUBLICATIONS
 

  1. Elizabeth R. Butch, Paul E. Mead, Victor Amador-Diaz, Heather Tillman, Elizabeth Stewart, Jitendra K. Mishra, Jieun Kim, Armita Bahrami, Jason L.J. Dearling, Alan B. Packard, Shana V. Stoddard, Amy L.Vāvere, Yuanyuan Han, Barry L. Shulkin, and Scott E. Snyder. Variable In Vivo Expression of Disiaganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma Determined Using Positron Emission Tomography. Cancer Research (2019) 79: 1-13
     
  2. Shana V. Stoddard, Colin L. Welsh, Maggie M. Palopoli, Serena D. Stoddard, Mounika P. Aramandla, Riya M. Patel, and Laurence H. Beck, Jr.Structure and Function Insights Garnered from In silico Modelling of the Thrombospondin Type-1 Domain-Containing 7A Antigen.  PROTEINS: Structure, Function, Bioinformatics.  Proteins. 2018 Dec 06. PMID: 30520531
     
  3. Shana V. Stoddard, Xavier A. May, Fatima Rivas, Kyra Dodson, Sajith Vijayan, Swetha Adhika, Kordarius Parker, Davita L. Watkins.  Design of Potent Panobinostat Histone Deacetylase Inhibitor Derivatives: Molecular Considerations for Enhanced Isozyme Selectivity between Histone Deacetylase 2 (HDAC2) and Histone Deacetylase 8 (HDAC8) Molecular Informatics 37 (2018) 1800080
     
  4. In Silico Design and Evaluation of Carboxylesterase Inhibitors, Shana V. Stoddard, Xiaozhen Yu, Philip M. Potter, Randy M. Wadkins. Journal of Pesticide Science 35 (2010) 240-249
     
  5. In Silico Design and Evaluation of Carboxylesterase Inhibitors, Shana V. Stoddard, Xiaozhen Yu, Philip M. Potter, Randy M. Wadkins. Journal of Pesticide Science 35 (2010) 240-249
     
  6. Improved, Selective, Human Intestinal Carboxylesterase Inhibitors Designed to Modulate CPT-11 Toxicity, Latorya D. Hicks, Janice L. Hyatt, Shana Stoddard, Lyudmila Tsurkan, Carol C. Edward, Monika Wierdl, Randy M. Wadkins, Philip M. Potter. Journal of Medicinal Chemistry 52 (2009) 3742-3752

 

Underlined names are Student Co-Authors

SELECTED PRESENTATIONS

  1. Shana V. Stoddard. Computational Insights into the Structure and Epitope locations for Two Idiopathic Membranous Nephropathy Antigens: Phospholipase A2 Receptor and the Thrombospondin Type-1 Containing Domain 7A and Design of Antigen Binding Proteins. American Society for Biochemistry and Molecular Biology Annual National Meeting. San Diego, CA (April 2018)
     
  2. Barry Rich, Emma Goldman, Caylon Martin*,  Shana V. Stoddard, Kimberly A. Brien. Synthesis and Computational Evaluation of Vorinostat Boron Derivatives as Potential Histone Deacetylase Inhibitors. 255th ACS National Meeting, New Orleans, LA (March 2018)
     
  3. Sakura Horiuchi, Zara Parkinson, Colin L. Welsh, Kimberly Brien, R. de la Salud Bea, Shana V. Stoddard.  Synthesis of Mutated Peptides and Computational Evaluation of the FNII Domain of the PLA2R Antigen in Idiopathic Membranous Nephritis to Determine the Epitope Regions. 255th ACS National Meeting, New Orleans, LA (March 2018)
     
  4. Zara Parkinson, Sakura Horiuchi, Candace A. Hayes, Colin L. Welsh, Kimberly Brien, R. de la Salud Bea, Shana V. Stoddard.  Synthesis of Mutated Peptides and Computational Evaluation of the CTLD1 Domain on the PLA2R Antigen in Idiopathic Membranous Nephritis to Determine Epitope Sites Locations. 255th ACS National Meeting, New Orleans, LA (March 2018)
     
  5. Caylon Martin*, Xavier A. May, Swetha Adhika, Davita L. Watkins, Kimberly Brien, and Shana V. Stoddard.  Evaluation of panobinostat and vorinostat boron derivatives as potential histone deacetylase inhibitors. Southeastern Regional Meeting of the American Chemical Society (SERMACS) Charlotte, NC (November 2017)
     
  6. AliReza Zaravar and Shana V. Stoddard. Rational design of epitope binding monobodies: New tools for autoimmune therapy. Southeastern Regional Meeting of the American Chemical Society (SERMACS) Charlotte, NC (November 2017)
     
  7. Itthipoaln Rasasack and Shana V. Stoddard. Development of antigen-specific blocking monobodies against the phospholipase A2 receptor for the inhibition of idiopathic membranous nephropathy Southeastern Regional Meeting of the American Chemical Society (SERMACS) Charlotte, NC  (November 2017)
     
  8. Omar Stocks, Liam Goldman, and Shana V. Stoddard. Computational identification and characterization of the epitope regions in the C-type lectin domain number seven (CTLD7) of the phospholipase A2 receptor for development of epitope binding monobodies. Southeastern Regional Meeting of the American Chemical Society (SERMACS) Charlotte, NC (November 2017)
     
  9. Shana V. Stoddard, AliReza Zaravar, Xavier May, Liam Goldman Development of Phospholipase A2 Receptor Antigen Binding Monobodies for the Inhibition of the Idiopathic Membranous Glomerulonephritis Auto-antibody Binding. Southeastern Regional Meeting of the American Chemical Society (SERMACS) Charlotte, NC (November 2017)
     
  10. Zara Parkinson, Zain Virk, Anoushka Mullasseril, Kimberly Brien, Roberto de la Salud Bea, Shana V. Stoddard. Synthesis of Peptides Modeling Domains on PLA2R, 45th ACS National Organic Symposium, Davis, CA (June 2017)
     
  11. Shana V. Stoddard, AliReza Zaravar, Xavier May, Liam Goldman Development of Phospholipase A2 Receptor Antigen Binding Monobodies for the Inhibition of the Idiopathic Membranous Glomerulonephritis Auto-antibody Binding. American Society for Biochemistry and Molecular Biology Annual National Meeting. Chicago, IL (April 2017)
     
  12. AliReza Zaravar, Xavier May, Shana V. Stoddard. Rational Design of Epitope Binding Monobodies: New Tools for Autoimmune Therapy. American Society for Biochemistry and Molecular Biology Annual National Meeting. Chicago, IL (April 2017)
     
  13. Xavier May, Davita Watkins, Shana V. Stoddard. Identification of Molecular Interactions within Histone Deacetylase Isozymes for the Development of Potent HDAC2 Inhibitors for the Design of Targeted Cancer Therapies. American Society for Biochemistry and Molecular Biology Annual National Meeting. Chicago, IL (April 2017)
     
  14. Shana V. Stoddard, Elizabeth R. Butch, Amy, L. Vāvere, Jason L. J. Dearling, Alan B. Packard, Barry L. Shulkin, Scott E. Snyder. Synthesis, characterization, and in vivo evaluation of novel GD2 targeting PET radiotracer for patient stratification in osteosarcoma, melanoma, and neuroblastoma: 41st Annual Conference for National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE), September23rd – 29th, 2014, New Orleans, LA
     
  15. Shana V. Stoddard, Elizabeth R. Butch, Amy, L. Vāvere, Jason L. J. Dearling, Alan B. Packard, Barry L. Shulkin, Scott E. Snyder. Preparation and preliminary evaluation of novel GD2 targeting PET radiotracer for patient stratification in Osteosarcoma, Melanoma, and Neuroblastoma:, Gordon Research Conference, Antibody Biology and Engineering March 24th – 28th, 2014: Tuscany, Italy
     
  16. Shana V. Stoddard, Elizabeth R. Butch, Amy, L. Vāvere, Jason L. J. Dearling, Alan B. Packard, Barry L. Shulkin, Scott E. Snyder. Preparation and preliminary evaluation of novel GD2 targeting PET radiotracer for patient stratification in Osteosarcoma, Melanoma, and Neuroblastoma: Gordon Research Seminar, Antibody Biology and Engineering March 22nd – 23rd, 2014: Tuscany, Italy  

* Student with Asterisk (Grad Academy High School Student)